The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1810171 Abstract BACKGROUND Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, has robust efficacy in patients with ALK-positive...Read More
Author: Physicians Weekly
The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.
Cell reports 25(1) 80-94 pii 10.1016/j.celrep.2018.09.012 Abstract We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood...Read More
Cells 2018 10 017(10) pii 10.3390/cells7100155 Abstract Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably...Read More
Positive and negative regulation of cellular immune responses in physiologic conditions and diseases.
Clinical & developmental immunology 2012 03 262012() 485781 doi 10.1155/2012/485781 Abstract The immune system has evolved to allow robust responses against pathogens while avoiding autoimmunity. This is notably enabled by...Read More
Angewandte Chemie (International ed. in English) 2017 11 2857(16) 4143-4148 doi 10.1002/anie.201708408 Abstract Tailor-made: Discussed herein is the ability to adapt biology’s mechanisms for innovation and optimization to...Read More
Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.
Proceedings of the National Academy of Sciences of the United States of America 90(12) 5618-22 Abstract Random mutagenesis has been used to engineer the protease subtilisin E to function in a highly nonnatural...Read More
Sports medicine (Auckland, N.Z.) 44 Suppl 2() S175-84 doi 10.1007/s40279-014-0257-8 Abstract Caffeine is a popular work-enhancing supplement that has been actively researched since the 1970s. The majority of research has...Read More
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
The EMBO journal 11(11) 3887-95 Abstract The classical type of programmed cell death is characterized by its dependence on de novo RNA and protein synthesis and morphological features of apoptosis. We confirmed that stimulated...Read More
Cancer 2012 04 27118(22) 5623-9 doi 10.1002/cncr.27598 Abstract BACKGROUND Completion of the human papillomavirus (HPV) vaccine in a large percentage of young females is an important goal to prevent anogenital cancers associated...Read More