Photodynamic therapy in dermatology beyond non-melanoma cancer: an update.

Photodynamic therapy in dermatology beyond non-melanoma cancer: an update.
Author Information (click to view)

Wen X, Li Y, Hamblin MR,


Wen X, Li Y, Hamblin MR, (click to view)

Wen X, Li Y, Hamblin MR,

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Photodiagnosis and photodynamic therapy 2017 06 21() pii S1572-1000(17)30235-1
Abstract

Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.

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